Containment Barrier Isolator - III (CBI-III)
Containment Barrier Isolator - III (CBI-III)
Your Practical Solution to cGMP Compliance
Containment Barrier Isolator - Class III Biosafety Cabinet (CBI-III) offers the highest level of operator, product, and environmental protection from infectious/biohazardous aerosols and is suitable for microbiological work with agents assigned to biosafety levels 1,2,3, or 4. It is designed for an absolute level of containment, it is frequently used for work involving the deadliest biohazards, bacteria, viruses, and microorganisms.
CBI-III is configured to operate at a minimum of -125 Pa to provide adequate containment for handling highly pathogenic and lethal biological agents.
Applications:
● Laboratory containment for handling biological agents of up to level 4
● Virus and vaccine production
● Cell Processing
● Research and development
Features
● Fully welded stainless steel 316L internal chambers with stainless steel 304 external housingg
● Exhaust air is double-filtered through high-quality ULPA filters (per IEST-RP-CC-001.3) with typical efficiency of >99.999% for 0.1 to 0.3 micron particles, better than HEPA filters.
● An integrated pass-through with interlocking doors permits materials transfer without risk of contamination
● Single-piece, leak-tested glove assemblies which guarantee maximum protection.
Principle
● Ambient air is pulled through the inlet prefilter located on top of the isolator. Air from the top inlet and from work zone is pulled by the fan which creates a positive pressure on the plenum that creates downflow. The HEPA (H14) downflow filter creates a laminar and particle-free ISO Class 5 air cleanliness as per ISO 14644-1 (equivalent to Class 1 as per US Fed Std 209E) inside the isolator to protect the work material inside the main chamber and pass-thru. Air from the work zone and pass-thru is quickly purged out by the fan to keep the area clean. The fan pulls approximately 90% of the purged air back to the plenum and after passing through the HEPA (H14) downflow filter.
● The high rate of airflow recirculation helps to prolong filter life and reduces the chances of ambient contaminants entering the work zone. For a recirculating model, approximately 10% of the purged air is exhausted through an HEPA-filter to prevent heat build-up inside the isolator that can be detrimental to drug compounding. This exhausted air is replenished by ambient air coming from the top inlet prefilter and a filter with 80% efficiency for positive pressure model. For a Total Exhaust/Single-Pass Model, 100% of the air is exhausted out of the isolator.
